According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Abstract Characterization of somatic mutations at single-cell resolution is essential to study
cancer evolution, clonal mosaicism and cell plasticity. Here, we describe SComatic, an …

Adoptive cell therapy (ACT) using ex vivo–expanded tumor-infiltrating lymphocytes (TILs)
can eliminate or shrink metastatic melanoma, but its long-term efficacy remains limited to a …

High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous
recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to …

The digitization of health records and growing availability of tumour DNA sequencing
provide an opportunity to study the determinants of cancer outcomes with unprecedented …

The drivers of recurrence and resistance in ovarian high grade serous carcinoma remain
unclear. We investigate the acquisition of resistance by collecting tumour biopsies from a …

Advanced high-grade serous ovarian cancer (HGSC) is an aggressive disease that
accounts for 70% of all ovarian cancer deaths. Nevertheless, 15% of patients diagnosed …

Chromosomal instability (CIN) is a hallmark of cancer and a driver of metastatic
dissemination, therapeutic resistance, and immune evasion. CIN is present in 60–80% of …

The drivers of immune evasion are not entirely clear, limiting the success of cancer
immunotherapies. Here we applied single-cell spatial and perturbational transcriptomics to …