An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions

GM Slavich, LG Roos, S Mengelkoch… - Health psychology …, 2023 - Taylor & Francis
Classic theories of stress and health are largely based on assumptions regarding how
different psychosocial stressors influence biological processes that, in turn, affect human …

The complex aetiology of cerebral palsy

SJ Korzeniewski, J Slaughter, M Lenski… - Nature Reviews …, 2018 - nature.com
Cerebral palsy (CP) is the most prevalent, severe and costly motor disability of childhood.
Consequently, CP is a public health priority for prevention, but its aetiology has proved …

The role of inflammation in perinatal brain injury

H Hagberg, C Mallard, DM Ferriero… - Nature Reviews …, 2015 - nature.com
Inflammation is increasingly recognized as being a critical contributor to both normal
development and injury outcome in the immature brain. The focus of this Review is to …

Maternal immune activation and abnormal brain development across CNS disorders

I Knuesel, L Chicha, M Britschgi, SA Schobel… - Nature Reviews …, 2014 - nature.com
Epidemiological studies have shown a clear association between maternal infection and
schizophrenia or autism in the progeny. Animal models have revealed maternal immune …

Long-term risk of neuropsychiatric disease after exposure to infection in utero

BJS Al-Haddad, B Jacobsson, S Chabra… - JAMA …, 2019 - jamanetwork.com
Importance The developmental origins of mental illness are incompletely understood.
Although the development of autism and schizophrenia are linked to infections during fetal …

Microglia regulate the number of neural precursor cells in the develo** cerebral cortex

CL Cunningham, V Martínez-Cerdeño… - Journal of …, 2013 - Soc Neuroscience
Neurogenesis must be properly regulated to ensure that cell production does not exceed the
requirements of the growing cerebral cortex, yet our understanding of mechanisms that …

Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

L Bergdolt, A Dunaevsky - Progress in neurobiology, 2019 - Elsevier
The develo** brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …

Prenatal poly (i: C) exposure and other developmental immune activation models in rodent systems

U Meyer - Biological psychiatry, 2014 - Elsevier
It is increasingly appreciated that altered neuroimmune mechanisms might play a role in the
development of schizophrenia and related psychotic illnesses. On the basis of human …