The mammalian retina provides an excellent opportunity to study glia–neuron interactions
and the interactions of glia with blood vessels. Three main types of glial cells are found in …

Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the
precise roles are not known. Understanding these complex processes, which may also be a …

There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …

Glaucoma is a multifactorial neurodegenerative disorder affecting 80 million people
worldwide. Loss of retinal ganglion cells and degeneration of their axons in the optic nerve …

Glaucoma causes loss of vision through degeneration of the retinal ganglion cell (RGC)
projection to the brain. The disease is characterized by sensitivity to intraocular pressure …

Astrocytes are the most abundant glial cells in the brain and are responsible for diverse
functions, from modulating synapse function to regulating the blood–brain barrier. In vivo …

Inflammatory responses play a key role in many neural pathologies, with localized signaling
from the non-immune cells making critical contributions. The NLRP3 inflammasome is an …

Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline
with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus …