The effects of current treatment strategies for ischemic stroke are weakened by ischemia-
reperfusion (I/R) injury. Effective treatments targeting I/R injury are still insufficient …

Stroke seriously threatens human health because of its characteristics of high morbidity,
disability, recurrence, and mortality, thus representing a heavy financial and mental burden …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity
whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis …

Background Microglia-induced excessive neuroinflammation plays a crucial role in the
pathophysiology of multiple neurological diseases, such as ischaemic stroke. Controlling …

Existing guidelines on the preparation (Planning Research and Experimental Procedures on
Animals: Recommendations for Excellence (PREPARE)) and reporting (Animal Research …

Stroke may cause severe death and disability but many clinical trials have failed in the past,
partially because the lack of an effective method to regenerate new neurons after stroke. In …

Excessive and unresolved neuroinflammation is a key component of the pathological
cascade in brain injuries such as ischemic stroke. Tripartite motif-containing 45 (TRIM45) is …

Increasing focus on issues of research reproducibility affords us the opportunity to review
some of the key issues related in vivo research. First, we set out some key definitions, to …