Microneedles (MN) have the potential to become a highly progressive device for both drug
delivery and monitoring purposes as they penetrate the skin and pierce the stratum corneum …

When faced with vaccine hesitancy, public health authorities are looking for effective
strategies to address this issue. In this paper, the findings of 15 published literature reviews …

This Clinical Report was revised. See https://doi. org/10.1542/peds. 2023-065483.
Immunizations have led to a significant decrease in rates of vaccine-preventable diseases …

Introduction Prevention and treatment of pain in pediatric patients compared with adults is
often not only inadequate but also less often implemented the younger the children are …

Background: Vaccine injections are the most common painful needle procedure
experienced throughout the lifespan. Many strategies are available to mitigate this pain; …

Guidelines 976 CMAJ, September 22, 2015, 187 (13) mendations Assessment,
Development and Evaluation)(www. grade working group. org/publications/jce_series. htm) …

Background Infant acute pain and distress is commonplace. Infancy is a period of
exponential development. Unrelieved pain and distress can have implications across the …

Needle fears are a documented barrier to immunization in children and adults. There is a
paucity of data, however, regarding the prevalence of needle fears and their impact on …

Objective To systematically review the evidence (and quality) for distraction and hypnosis for
needle-related pain and distress in children and adolescents. To explore the effects of …

Background This is the second update of a Cochrane Review (Issue 4, 2006). Pain and
distress from needle‐related procedures are common during childhood and can be reduced …