Panax ginseng against myocardial ischemia/reperfusion injury: A review of preclinical evidence and potential mechanisms

J Chen, Q Huang, J Li, Y Yao, W Sun, Z Zhang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Panax ginseng CA Meyer (P. ginseng) is effective in the
prevention and treatment of myocardial ischemia-reperfusion (I/R) injury. The mechanism by …

Reactive oxygen species-mediated cardiac-reperfusion injury: mechanisms and therapies

F Bagheri, V Khori, AM Alizadeh, S Khalighfard… - Life Sciences, 2016 - Elsevier
Reperfusion injury is an inherent response to the restoration of blood flow after ischemia. It is
a complex process involving numerous mechanisms occurring in the intracellular and …

Attenuation of TNF-α-induced inflammatory injury in endothelial cells by ginsenoside Rb1 via inhibiting NF-κB, JNK and p38 signaling pathways

P Zhou, S Lu, Y Luo, S Wang, K Yang, Y Zhai… - Frontiers in …, 2017 - frontiersin.org
It is currently believed that inflammation plays a central role in the pathophysiology of
atherosclerosis. Oxidative stress and redox-sensitive transcription factors are implicated in …

[HTML][HTML] Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax …

Z Lin, R **e, C Zhong, J Huang, P Shi, H Yao - Journal of ginseng research, 2022 - Elsevier
Abstract Ginsenoside Rb 1 (Rb 1), one of the most important ingredients in Panax ginseng
Meyer, has been confirmed to have favorable activities, including reducing antioxidative …

Inhibition of myocardial cell apoptosis is important mechanism for ginsenoside in the limitation of myocardial ischemia/reperfusion injury

Z Chen, J Wu, S Li, C Liu, Y Ren - Frontiers in Pharmacology, 2022 - frontiersin.org
Ischemic heart disease has a high mortality, and the recommended therapy is reperfusion.
Nevertheless, the restoration of blood flow to ischemic tissue leads to further damage …

Ginsenosides for cardiovascular diseases; update on pre-clinical and clinical evidence, pharmacological effects and the mechanisms of action

M Sarhene, JY Ni, ES Duncan, Z Liu, S Li… - Pharmacological …, 2021 - Elsevier
Cardiovascular disease (CVD) remains the major cause of death worldwide, accounting for
almost 31% of the global mortality annually. Several preclinical studies have indicated that …

Neuroprotective effects of radix scrophulariae on cerebral ischemia and reperfusion injury via MAPK pathways

X Meng, W **e, Q Xu, T Liang, X Xu, G Sun, X Sun - Molecules, 2018 - mdpi.com
Ischemic stroke is a clinically common cerebrovascular disease whose main risks include
necrosis, apoptosis and cerebral infarction, all caused by cerebral ischemia and reperfusion …

Mitochondrial dysfunction in heart diseases: Potential therapeutic effects of Panax ginseng

X Cao, F Yao, B Zhang, X Sun - Frontiers in Pharmacology, 2023 - frontiersin.org
Heart diseases have a high incidence and mortality rate, and seriously affect people's
quality of life. Mitochondria provide energy for the heart to function properly. The process of …

Ginsenoside Rb1 and mitochondria: a short review of the literature

P Zhou, W **e, Y Sun, Z Dai, G Li, G Sun… - Molecular and Cellular …, 2019 - Elsevier
Mitochondria play a central role in various critical cellular processes, including energy
synthesis, energy supply and apoptosis. Panax notoginseng, a commonly used traditional …

Inhibitory effects of ginsenoside Rb1 on early atherosclerosis in ApoE-/-mice via inhibition of apoptosis and enhancing autophagy

P Zhou, W **e, Y Luo, S Lu, Z Dai, R Wang, X Zhang… - Molecules, 2018 - mdpi.com
Inflammation is a major contributing factor to the progression of atherosclerosis.
Ginsenoside Rb1 (Rb1), an active saponin of Panax notoginseng, has been found to exert …