[HTML][HTML] Triglyceride metabolism in the liver

M Alves-Bezerra, DE Cohen - Comprehensive physiology, 2017 - ncbi.nlm.nih.gov
Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Protein quality control and lipid droplet metabolism

MA Roberts, JA Olzmann - Annual review of cell and …, 2020 - annualreviews.org
Lipid droplets (LDs) are endoplasmic reticulum–derived organelles that consist of a core of
neutral lipids encircled by a phospholipid monolayer decorated with proteins. As hubs of …

Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation

K Bersuker, JA Olzmann - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Lipid droplets (LDs) are ubiquitous, endoplasmic reticulum (ER)-derived organelles that
mediate the sequestration of neutral lipids (eg triacylglycerol and sterol esters), providing a …

Selenium and selenoproteins in adipose tissue physiology and obesity

AA Tinkov, OP Ajsuvakova, T Filippini, JC Zhou, XG Lei… - Biomolecules, 2020 - mdpi.com
Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its
possible roles in obesity development and in adipocyte metabolism are unclear. The …

Lipid droplets, lipophagy, and beyond

CW Wang - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2016 - Elsevier
Lipids are essential components for life. Their various structural and physical properties
influence diverse cellular processes and, thereby, human health. Lipids are not genetically …

Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia

C Bruedigam, AH Porter, A Song, G Vroeg in de Wei… - Nature Cancer, 2024 - nature.com
Telomerase enables replicative immortality in most cancers including acute myeloid
leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in …

Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes

T D'Aquila, YH Hung, A Carreiro, KK Buhman - Biochimica et Biophysica …, 2016 - Elsevier
Dietary fat provides essential nutrients, contributes to energy balance, and regulates blood
lipid concentrations. These functions are important to health, but can also become …

Protein correlation profiles identify lipid droplet proteins with high confidence

N Krahmer, M Hilger, N Kory, F Wilfling, G Stoehr… - Molecular & Cellular …, 2013 - ASBMB
Lipid droplets (LDs) are important organelles in energy metabolism and lipid storage. Their
cores are composed of neutral lipids that form a hydrophobic phase and are surrounded by …

Mammalian lipid droplets: Structural, pathological, immunological and anti-toxicological roles

N Hammoudeh, C Soukkarieh, DJ Murphy… - Progress in lipid …, 2023 - Elsevier
Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral
lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific …

The new face of the lipid droplet: lipid droplet proteins

C Zhang, P Liu - Proteomics, 2019 - Wiley Online Library
The lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD
proteomic research has provided fundamentally important insights into this organelle's …