Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

Although no single animal model replicates all aspects of diabetes mellitus in humans,
animal models are essential for the study of energy balance and metabolism control as well …

Although the function of the mammalian pancreas hinges on complex interactions of distinct
cell types, gene expression profiles have primarily been described with bulk mixtures. Here …

The arrangement of β cells within islets of Langerhans is critical for insulin release through
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …

Alzheimer disease and type 2 diabetes are characterized by increased prevalence with
aging, a genetic predisposition, and comparable pathological features in the islet and brain …

Islet amyloid polypeptide (IAPP), a putative polypeptide hormone, is a product of pancreatic
beta-cells and the major constituent of the amyloid deposits seen mainly in islets of type 2 …

Substantial evidence shows that skeletal fragility should be considered among the
complications associated with type 2 diabetes. Individuals with type 2 diabetes have …

Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits
contain the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in …

Islet amyloid polypeptide (IAPP) has been identified as the major constituent of the
pancreatic amyloid of non-insulin-dependent diabetes mellitus (NIDDM) and is also present …

In 1960, immunoassays of insulin first demonstrated significant quantities of circulating
hormone in non-insulin-dependent (type II) diabetes and for 30 yr have fostered debate as to …