Multiple sclerosis (MS) is a common autoimmune disease that targets myelin in the central
nervous system (CNS). Multiple genome-wide association studies (GWAS) over the past 10 …

Differences in transcription factor binding can contribute to organismal evolution by altering
downstream gene expression programmes. Genome-wide studies in Drosophila …

INTRODUCTION Multiple sclerosis (MS) is an inflammatory and degenerative disease of the
central nervous system (CNS) that often presents in young adults. Over the past decade …

CTCF-binding locations represent regulatory sequences that are highly constrained over the
course of evolution. To gain insight into how these DNA elements are conserved and spread …

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …

We determined genome-wide nucleosome occupancies in mouse embryonic stem cells and
their neural progenitor and embryonic fibroblast counterparts to assess features associated …

ABSTRACT CTCF is a highly conserved zinc-finger DNA-binding protein that mediates
interactions between distant sequences in the genome. As a consequence, CTCF regulates …

The multifunctional CCCTC-binding factor (CTCF) protein exhibits a broad range of
functions, including that of insulator and higher-order chromatin organizer. We found that …

Proteins with sequence-specific DNA binding function are important for a wide range of
biological activities. De novo prediction of their DNA-binding specificities from sequence …

Background The binding of transcription factors to specific locations in the genome is
integral to the orchestration of transcriptional regulation in cells. To characterize transcription …