Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

This review describes a multidimensional treatment of molecular recognition phenomena
involving aromatic rings in chemical and biological systems. It summarizes new results …

Interactions between proteins are orchestrated in a precise and time-dependent manner,
underlying cellular function. The binding affinity, defined as the strength of these …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

The> 800 human G protein–coupled receptors (GPCRs) are responsible for transducing
diverse chemical stimuli to alter cell state-and are the largest class of drug targets. Their …

In addition to the serotonin 5-HT2A receptor (5-HT2AR), the dopamine D2 receptor (D2R) is
a key therapeutic target of antipsychotics for the treatment of schizophrenia. The inactive …

Mutationally constrained epitopes of variable pathogens represent promising targets for
vaccine design but are not reliably identified by sequence conservation. In this study, we …

Sulfur atoms have been known to participate in hydrogen bonds (H‐bonds) and these sulfur‐
containing H‐bonds (SCHBs) are suggested to play important roles in certain biological …

Pathological remodeling of the myocardium has long been known to involve oxidant
signaling, but strategies using systemic antioxidants have generally failed to prevent it. We …