The primary cilium is a signaling compartment that interprets Hedgehog signals through
changes of its protein, lipid, and second messenger compositions. Here, we combine …

Cancer cells are distinguished from normal cells by increased proliferation and metabolism,
loss of polarity control, and the potential to invade other tissues of the body. As hubs of …

The primary cilium permits compartmentalization of specific signaling pathways, including
elements of the Hedgehog (Hh) pathway. Hh transcriptional activity is thought to be …

Background Ciliary dysfunction underlies a range of genetic disorders collectively termed
ciliopathies, for which there are no treatments available. Bardet-Biedl syndrome (BBS) is …

ELMODs are a family of three mammalian paralogues that display GTPase-activating protein
(GAP) activity toward a uniquely broad array of ADP-ribosylation factor (ARF) family …

Primary cilia are critical sensory and signaling compartments present on most mammalian
cell types. These specialized structures require a unique signaling protein composition …

Background: Rab35 is a member of a GTPase family of endocytic trafficking proteins.
Studies in cell lines have indicated that Rab35 participates in cell adhesion, polarity …

Optical approaches have revolutionized our view of second messenger signaling in
organelles, allowing precise time-resolved assessment of soluble signaling molecules in …

Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at
high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide …

The primary cilium is a signaling compartment that interprets Hedgehog signals through
changes of its protein, lipid and second messenger compositions. Here, we combine …