[HTML][HTML] Excess body weight: Novel insights into its roles in obesity comorbidities
Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet,
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …
Metabolic rearrangements in primary liver cancers: cause and consequences
L Satriano, M Lewinska, PM Rodrigues… - Nature reviews …, 2019 - nature.com
Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …
IFNα potentiates anti–PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment
B Hu, M Yu, X Ma, J Sun, C Liu, C Wang, S Wu, P Fu… - Cancer Discovery, 2022 - AACR
The overall response rate for anti–PD-1 therapy remains modest in hepatocellular
carcinoma (HCC). We found that a combination of IFNα and anti–PD-1–based …
carcinoma (HCC). We found that a combination of IFNα and anti–PD-1–based …
[HTML][HTML] N6-methyladenosine–mediated up-regulation of FZD10 regulates liver cancer stem cells' properties and lenvatinib resistance through WNT/β-catenin and …
J Wang, H Yu, W Dong, C Zhang, M Hu, W Ma, X Jiang… - Gastroenterology, 2023 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-
related deaths worldwide, but there is a deficiency of early diagnosis biomarkers and …
related deaths worldwide, but there is a deficiency of early diagnosis biomarkers and …
Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target
Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an
emerging malignancy in the developed world; however, mechanisms that contribute to its …
emerging malignancy in the developed world; however, mechanisms that contribute to its …
Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase
Background & Aims Streptococcus thermophilus was identified to be depleted in patients
with colorectal cancer (CRC) by shotgun metagenomic sequencing of 526 multicohort fecal …
with colorectal cancer (CRC) by shotgun metagenomic sequencing of 526 multicohort fecal …
[HTML][HTML] High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate
P Zhou, W Chang, D Gong, J **a, W Chen, L Huang… - Cell Metabolism, 2023 - cell.com
Emerging studies have addressed the tumor-promoting role of fructose in different cancers.
The effects and pathological mechanisms of high dietary fructose on hepatocellular …
The effects and pathological mechanisms of high dietary fructose on hepatocellular …
Cold shock proteins: from cellular mechanisms to pathophysiology and disease
JA Lindquist, PR Mertens - Cell Communication and Signaling, 2018 - Springer
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …
presence of one or more cold shock domains. In humans, the best characterized members of …
Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma
Conclusions: Our work provides the first detailed spatial map of single-cell phenotypes and
multicellular connections in NASH-HCC. We demonstrate that interactions between MDSCs …
multicellular connections in NASH-HCC. We demonstrate that interactions between MDSCs …
Role and function of O-GlcNAcylation in cancer
Simple Summary Despite the rapid advancement in immunotherapy and targeted agents,
many patients diagnosed with cancer have poor prognosis with dismal overall survival. One …
many patients diagnosed with cancer have poor prognosis with dismal overall survival. One …