Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …

Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread enzymes in all organisms,
catalyzing CO2 hydration to bicarbonate and protons. Their inhibition is exploited clinically …

A series of 7-substituted coumarins incorporating various glycosyl moieties were
synthesized and investigated for the inhibition of the zinc enzyme carbonic anhydrase (CA …

Specific isoforms from the carbonic anhydrase (CA) family of zinc metalloenzymes have
been associated with a variety of diseases. Isoform-specific carbonic anhydrase inhibitors …

A series of polyphenolic derivatives, including resveratrol, dobutamine, curcumin, catechin
and silymarine were investigated for the inhibition of all the catalytically active mammalian …

Two series of disubstituted coumarins incorporating ether and acetyl/propionyl moieties in
positions 6, 7-and 7, 8-of the heterocyclic ring were synthesized investigated for the …

A series of coumarins incorporating hydroxy-, chloro-and/or chloromethyl-moieties in
positions 3-, 4-, 6-and 7-of the heterocyclic ring were investigated for the inhibition of the …

Diabetes mellitus and obesity are one of the most common health issues spread throughout
world and raised the medical attention to find the new effective agents to treat these disease …

A series of flavonoids, such as quercetin, catechin, apigenin, luteolin, morin, were
investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA) …