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Molecular mechanisms of transcription-coupled repair
Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of
UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes …
UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes …
The DNA damage response to transcription stress
The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution
We developed a method for genome-wide map** of DNA excision repair named XR-seq
(excision repair sequencing). Human nucleotide excision repair generates two incisions …
(excision repair sequencing). Human nucleotide excision repair generates two incisions …
Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex
Failure in repairing ultraviolet radiation-induced DNA damage can lead to mutations and
cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is …
cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is …
Methodologies for detecting environmentally induced DNA damage and repair
W Li, A Sancar - Environmental and molecular mutagenesis, 2020 - Wiley Online Library
Environmental DNA damaging agents continuously challenge the integrity of the genome by
introducing a variety of DNA lesions. The DNA damage caused by environmental factors will …
introducing a variety of DNA lesions. The DNA damage caused by environmental factors will …
Single-nucleotide resolution dynamic repair maps of UV damage in Saccharomyces cerevisiae genome
We have adapted the eXcision Repair-sequencing (XR-seq) method to generate single-
nucleotide resolution dynamic repair maps of UV-induced cyclobutane pyrimidine dimers …
nucleotide resolution dynamic repair maps of UV-induced cyclobutane pyrimidine dimers …
Nucleotide excision repair of aflatoxin-induced DNA damage within the 3D human genome organization
Y Wu, MM Adeel, D ** of protein–DNA damage interaction by PADD-seq
Y Zhu, Y Tan, L Li, Y **ang, Y Huang… - Nucleic Acids …, 2023 - academic.oup.com
Protein–DNA damage interactions are critical for understanding the mechanism of DNA
repair and damage response. However, due to the relatively random distributions of UV …
repair and damage response. However, due to the relatively random distributions of UV …
Mediator roles going beyond transcription
KM André, EH Sipos, J Soutourina - Trends in Genetics, 2021 - cell.com
Dysfunctions of nuclear processes including transcription and DNA repair lead to severe
human diseases. Gaining an understanding of how these processes operate in the crowded …
human diseases. Gaining an understanding of how these processes operate in the crowded …
Transcription coupled nucleotide excision repair in the yeast Saccharomyces cerevisiae: The ambiguous role of Rad26
S Li - DNA repair, 2015 - Elsevier
Transcription coupled nucleotide excision repair (TC-NER) is believed to be triggered by an
RNA polymerase stalled at a lesion in the transcribed strand of actively transcribed genes …
RNA polymerase stalled at a lesion in the transcribed strand of actively transcribed genes …