Hepatitis E virus: advances and challenges
At least 20 million hepatitis E virus (HEV) infections occur annually, with> 3 million
symptomatic cases and∼ 60,000 fatalities. Hepatitis E is generally self-limiting, with a case …
symptomatic cases and∼ 60,000 fatalities. Hepatitis E is generally self-limiting, with a case …
Diseases in a dish: modeling human genetic disorders using induced pluripotent cells
G Tiscornia, EL Vivas, JCI Belmonte - Nature medicine, 2011 - nature.com
The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic
syndromes offers new opportunities for basic research into these diseases and the …
syndromes offers new opportunities for basic research into these diseases and the …
The INTACT method for cell type–specific gene expression and chromatin profiling in Arabidopsis thaliana
Genomic studies of cell differentiation and function within a whole organism depend on the
ability to isolate specific cell types from a tissue, but this is technically difficult. We developed …
ability to isolate specific cell types from a tissue, but this is technically difficult. We developed …
[HTML][HTML] A simple method for gene expression and chromatin profiling of individual cell types within a tissue
Understanding the production and function of specialized cells during development requires
the isolation of individual cell types for analysis, but this is currently a major technical …
the isolation of individual cell types for analysis, but this is currently a major technical …
Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells
P Douvaras, V Fossati - Nature protocols, 2015 - nature.com
In the CNS, oligodendrocytes act as the myelinating cells. Oligodendrocytes have been
identified to be key players in several neurodegenerative disorders. This protocol describes …
identified to be key players in several neurodegenerative disorders. This protocol describes …
[HTML][HTML] A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine-and xeno-free conditions
I Minami, K Yamada, TG Otsuji, T Yamamoto, Y Shen… - Cell reports, 2012 - cell.com
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced
pluripotent stem cells, are potentially useful in regenerative therapies for heart disease. For …
pluripotent stem cells, are potentially useful in regenerative therapies for heart disease. For …
Kidney organoids: a translational journey
Human pluripotent stem cells (hPSCs) are attractive sources for regenerative medicine and
disease modeling in vitro. Directed hPSC differentiation approaches have derived from …
disease modeling in vitro. Directed hPSC differentiation approaches have derived from …
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence
M Yoshimoto, P Porayette, NL Glosson… - Blood, The Journal …, 2012 - ashpublications.org
The extra-embryonic yolk sac (YS) is the first hematopoietic site in the mouse embryo and is
thought to generate only primitive erythroid and myeloerythroid progenitor cells before …
thought to generate only primitive erythroid and myeloerythroid progenitor cells before …
Engrafted human stem cell–derived hepatocytes establish an infectious HCV murine model
The demonstrated ability to differentiate both human embryonic stem cells (hESCs) and
patient-derived induced pluripotent stem cells (hiPSCs) into hepatocyte-like cells (HLCs) …
patient-derived induced pluripotent stem cells (hiPSCs) into hepatocyte-like cells (HLCs) …
Signalling pathways that control vertebrate haematopoietic stem cell specification
Haematopoietic stem cells (HSCs) are tissue-specific stem cells that replenish all mature
blood lineages during the lifetime of an individual. Clinically, HSCs form the foundation of …
blood lineages during the lifetime of an individual. Clinically, HSCs form the foundation of …