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Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease
Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
[HTML][HTML] How does neurovascular unit dysfunction contribute to multiple sclerosis?
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
(CNS) and the most common non-traumatic cause of neurological disability in young adults …
(CNS) and the most common non-traumatic cause of neurological disability in young adults …
Optical coherence tomography angiography (OCTA) in multiple sclerosis and neuromyelitis optica spectrum disorder
Vascular changes are increasingly recognized as important factors in the pathophysiology of
neuroinflammatory disease, especially in multiple sclerosis (MS). The relatively novel …
neuroinflammatory disease, especially in multiple sclerosis (MS). The relatively novel …
Nimodipine protects vascular and cognitive function in an animal model of cerebral small vessel disease
BACKGROUND: Cerebral small vessel disease is a common cause of vascular cognitive
impairment and dementia. There is an urgent need for preventative treatments for vascular …
impairment and dementia. There is an urgent need for preventative treatments for vascular …
From BBB to PPP: Bioenergetic requirements and challenges for oligodendrocytes in health and disease
Mature myelinating oligodendrocytes, the cells that produce the myelin sheath that insulates
axons in the central nervous system, have distinct energetic and metabolic requirements …
axons in the central nervous system, have distinct energetic and metabolic requirements …
Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis
Objective To establish a rigorous, expert-led, evidence-based approach to the evaluation of
licensed drugs for repurposing and testing in clinical trials of people with progressive …
licensed drugs for repurposing and testing in clinical trials of people with progressive …
Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis
The experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis was
used in combination with a Cav1. 2 conditional knock-out mouse (Cav1. 2KO) to study the …
used in combination with a Cav1. 2 conditional knock-out mouse (Cav1. 2KO) to study the …
Tissue hypoxia and associated innate immune factors in experimental autoimmune optic neuritis
Z Yang, C Marcoci, HK Öztürk, E Giama… - International Journal of …, 2024 - mdpi.com
Visual loss in acute optic neuritis is typically attributed to axonal conduction block due to
inflammatory demyelination, but the mechanisms remain unclear. Recent research has …
inflammatory demyelination, but the mechanisms remain unclear. Recent research has …
Investigating cortical hypoxia in multiple sclerosis via time‐domain near‐infrared spectroscopy
Objectives Hypoperfusion and tissue hypoxia have been implicated as contributory
mechanisms in the neuropathology of multiple sclerosis (MS). Our objective has been to …
mechanisms in the neuropathology of multiple sclerosis (MS). Our objective has been to …
Targeting neuroinflammation to alleviate chronic olfactory dysfunction in long covid: A role for investigating disease-modifying therapy (dmt)?
Chronic olfactory dysfunction after SARS-CoV-2 infection occurs in approximately 10% of
patients with COVID-19-induced anosmia, and it is a growing public health concern. A …
patients with COVID-19-induced anosmia, and it is a growing public health concern. A …