Modern drug discovery approaches often use high-content imaging to systematically study
the effect on cells of large libraries of chemical compounds. By automatically screening …

To comprehensively understand tissue and organism physiology and pathophysiology, it is
essential to create complete three-dimensional (3D) cellular maps. These maps require …

Measuring the phenotypic effect of treatments on cells through imaging assays is an efficient
and powerful way of studying cell biology, and requires computational methods for …

High-throughput screening techniques are commonly used to obtain large quantities of data
in many fields of biology. It is well known that artifacts arising from variability in the technical …

Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune
cells and act within the immunological synapse; an essential cell-to-cell interaction to direct …

The identification of genetic and chemical perturbations with similar impacts on cell
morphology can elucidate compounds' mechanisms of action or novel regulators of genetic …

Cell and organelle shape are driven by diverse genetic and environmental factors and thus
accurate quantification of cellular morphology is essential to experimental cell biology …

Advancements in high-throughput screenings enable the exploration of rich phenotypic
readouts through high-content microscopy, expediting the development of phenotype-based …

Data collected by high-throughput microscopy experiments are affected by batch effects,
stemming from slight technical differences between experimental batches. Batch effects …

Cell images, which have been widely used in biomedical research and drug discovery,
contain a great deal of valuable information that encodes how cells respond to external …