Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

G Livingston, J Huntley, KY Liu, SG Costafreda… - The Lancet, 2024 - thelancet.com
Executive summary The 2024 update of the Lancet Commission on dementia provides new
hopeful evidence about dementia prevention, intervention, and care. As people live longer …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Traumatic brain injury as a chronic disease: insights from the United States traumatic brain injury model systems research program

K Dams-O'Connor, SB Juengst, J Bogner… - The Lancet …, 2023 - thelancet.com
Traumatic brain injury (TBI) is a global health priority, associated with substantial burden.
Historically conceptualised as an injury event with finite recovery, TBI is now recognised as …

Magnesium–ibogaine therapy in veterans with traumatic brain injuries

KN Cherian, JN Keynan, L Anker, A Faerman… - Nature Medicine, 2024 - nature.com
Traumatic brain injury (TBI) is a leading cause of disability. Sequelae can include functional
impairments and psychiatric syndromes such as post-traumatic stress disorder (PTSD) …

A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets

RM Jha, D Rajasundaram, C Sneiderman, BT Schlegel… - Neuron, 2024 - cell.com
Traumatic brain injury (TBI) heterogeneity remains a critical barrier to translating therapies.
Identifying final common pathways/molecular signatures that integrate this heterogeneity …

Comparative effectiveness of intracranial pressure monitoring on 6-month outcomes of critically ill patients with traumatic brain injury

G Nattino, L Gamberini, O Brissy, G Carrara… - JAMA network …, 2023 - jamanetwork.com
Importance While the relationship between persistent elevations in intracranial pressure
(ICP) and poorer outcomes is well established for patients with traumatic brain injury (TBI) …

Intracranial pressure monitoring with and without brain tissue oxygen pressure monitoring for severe traumatic brain injury in France (OXY-TC): an open-label …

JF Payen, Y Launey, R Chabanne, S Gay… - The Lancet …, 2023 - thelancet.com
Background Optimisation of brain oxygenation might improve neurological outcome after
traumatic brain injury. The OXY-TC trial explored the superiority of a strategy combining …

Wrap** stem cells with wireless electrical nanopatches for traumatic brain injury therapy

L Wang, J Du, Q Liu, D Wang, W Wang, M Lei… - Nature …, 2024 - nature.com
Electrical stimulation holds promise for enhancing neuronal differentiation of neural stem
cells to treat traumatic brain injury. However, once the stem cells leave the stimulating …

Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?

MAM Freire, GS Rocha, LO Bittencourt, D Falcao… - Biology, 2023 - mdpi.com
Simple Summary Traumatic brain injury (TBI) is a catastrophic event to the health and life of
its sufferers, and it also affects their relatives. In addition to the underlying complications of …

Role of regulatory non-coding RNAs in traumatic brain injury

S Li, N Qiu, A Ni, MH Hamblin, KJ Yin - Neurochemistry international, 2024 - Elsevier
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …