The nematode Caenorhabditis elegans has been a model for studying infection since the
early 2000s and many major discoveries have been made regarding its innate immune …

Although the type‐I interferon (IFN‐I) response is considered vertebrate‐specific, recent
findings about the Intracellular Pathogen Response (IPR) in nematode Caenorhabditis …

Upon sensing viral RNA, mammalian RIG-I-like receptors (RLRs) activate downstream
signals using caspase activation and recruitment domains (CARDs), which ultimately …

Summary Toll/interleukin-1/resistance (TIR)-domain proteins with enzymatic activity are
essential for immunity in plants, animals, and bacteria. However, it is not known how these …

The genome of Caenorhabditis elegans encodes 284 nuclear hormone receptor, which
perform diverse functions in development and physiology. One of the best characterized of …

Innate immunity in bacteria, plants, and animals requires the specialized subset of
Toll/interleukin-1/resistance gene (TIR) domain proteins that are nicotinamide adenine …

Sphingolipids are required for diverse biological functions and are degraded by specific
catabolic enzymes. However, the mechanisms that regulate sphingolipid catabolism are not …

Infections, such as that by the multiresistant opportunistic bacterial pathogen Pseudomonas
aeruginosa, may pose a serious health risk, especially on vulnerable patient populations …

Pathogen avoidance behaviour has been observed across animal taxa as a vital host-
microbe interaction mechanism. The nematode Caenorhabditis elegans has evolved …

Effective responses against severe systemic infection require coordination between two
complementary defense strategies that minimize the negative impact of infection on the host …