Introduction: Immunization has been a remarkably successful public health intervention;
however, new approaches to vaccine design are essential to counter existing and emerging …

The targeted delivery of cancer drugs to tumor-specific molecular targets represents a major
challenge in modern personalized cancer medicine. Engineering of micron and submicron …

Engineered biocircuits designed with biological components have the capacity to expand
and augment living functions. Here we demonstrate that proteases can be integrated into …

During local and systemic inflammation, the complement system and neutrophil
granulocytes are activated not only by pathogens, but also by released endogenous danger …

Angioedema is the swelling of mucosal and sub-mucosal tissue. Typically, it manifests as
the swelling of the face, lips, and tongue. Angioedema can be severe and life threatening …

Hospital fabrics are commonly exposed to multiple patients and contaminated surfaces
between washing/sterilization cycles. Consequently, these textiles act as vectors for the …

Standard dead-end sample filtration is used to improve sample purity, but is limited as
particle build-up fouls the filter, leading to reduced recovery. The fouling layer can be …

Proteases are multi-functional enzymes that specialize in the hydrolysis of peptide-bonds
and control broad biological processes including homeostasis and allostasis. Moreover …

Proteases are multifunctional, promiscuous enzymes that degrade proteins as well as
peptides and drive important processes in health and disease. Current technology has …

The development of protease-activatable drugs and diagnostics requires identifying
substrates specific to individual proteases. However, this process becomes increasingly …