Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

The brain is the central organ involved in perceiving and adapting to social and physical
stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to …

Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However …

Coleoid cephalopods (octopus, squid and cuttlefish) are active, resourceful predators with a
rich behavioural repertoire. They have the largest nervous systems among the invertebrates …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of
transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB …

Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin
formation and gene silencing. It has a fundamental role in preserving genome stability …

Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …

Next-generation sequencing technologies have revolutionarily advanced sequence-based
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …

Although the human germline mutation rate is higher than that in any other well-studied
species, the rate is not exceptional once the effective genome size and effective population …