The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the
gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals …

Summary 15 years ago, the fundamental biology of an inflammatory signaling complex
eventually dubbed “the inflammasome” began to unravel in chronologic parallel with the …

The inflammatory microenvironment has been shown to play important roles in various
stages of tumor development including initiation, growth, and metastasis. The inflammasome …

Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

The respiratory tract is exceptionally well defended against infection from inhaled bacteria,
with multiple proinflammatory signaling cascades recruiting phagocytes to clear airway …