To what extent is the convergent evolution of protein function attributable to convergent or
parallel changes at the amino acid level? The mutations that contribute to adaptive protein …

Humans have adapted to the chronic hypoxia of high altitude in several locations, and
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …

The ecoevolutionary drivers of species niche expansion or contraction are critical for
biodiversity but challenging to infer. Niche expansion may be promoted by local adaptation …

Genomics is narrowing uncertainty in the phylogenetic structure for many amniote groups.
For one of the most diverse and species-rich groups, the squamate reptiles (lizards, snakes …

The tempo of species diversification in large clades can reveal fundamental evolutionary
mechanisms that operate on large temporal and spatial scales [1–4]. Hummingbirds have …

To investigate the predictability of genetic adaptation, we examined the molecular basis of
convergence in hemoglobin function in comparisons involving 56 avian taxa that have …

Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

Proteins are molecular machines composed of complex, highly connected amino acid
networks. Their functional optimization requires the reorganization of these intramolecular …

To cope with the reduced availability of O2 at high altitude, air-breathing vertebrates have
evolved myriad adjustments in the cardiorespiratory system to match tissue O2 delivery with …

Globins are haem‐proteins that bind O2 and thus play an important role in the animal's
respiration and oxidative energy production. However, globins may also have other …