Peripheral T cell lymphomas: from the bench to the clinic

D Fiore, LV Cappelli, A Broccoli, PL Zinzani… - Nature Reviews …, 2020 - nature.com
Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review

R Camicia, HC Winkler, PO Hassa - Molecular cancer, 2015 - Springer
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy
and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest …

Tafasitamab plus lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (L-MIND): a multicentre, prospective, single-arm, phase 2 study

G Salles, J Duell, EG Barca, O Tournilhac… - The Lancet …, 2020 - thelancet.com
Background Patients with relapsed or refractory diffuse large B-cell lymphoma who are
ineligible for autologous stem-cell transplantation have poor outcomes and few treatment …

A phase 2/3 multicenter, randomized, open-label study to compare the efficacy and safety of lenalidomide versus investigator's choice in patients with relapsed or …

MS Czuczman, M Trněný, A Davies, S Rule… - Clinical cancer …, 2017 - aacrjournals.org
Abstract Purpose: Randomized, multicenter, open-label, phase 2/3 trial investigating
lenalidomide versus investigator's choice (IC) in relapsed/refractory diffuse large B-cell …

Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma

NS Saba, D Liu, SEM Herman… - Blood, The Journal …, 2016 - ashpublications.org
To interrogate signaling pathways activated in mantle cell lymphoma (MCL) in vivo, we
contrasted gene expression profiles of 55 tumor samples isolated from blood and lymph …

Phase 1 study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreoretinal lymphoma

HW Tun, PB Johnston, LM DeAngelis… - Blood, The Journal …, 2018 - ashpublications.org
The combination of pomalidomide (POM) and dexamethasone (DEX) was evaluated for
relapsed/refractory primary central nervous system lymphoma (PCNSL) and primary …

S2k‐Guidelines–Cutaneous lymphomas (ICD10 C82‐C86): Update 2021

E Dippel, C Assaf, JC Becker… - Journal Der …, 2022 - pmc.ncbi.nlm.nih.gov
Cutaneous lymphomas (CL) are categorized as extranodal non-Hodgkin lymphomas,
constituting the second most common form in this group (MALT lymphomas of the stomach …

Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells

N Shenoy, T Bhagat, E Nieves, M Stenson… - Blood cancer …, 2017 - nature.com
Abstract The Ten Eleven Translocation (TET) enzymes have been found to be mutated in
both diffuse large B-cell (DLBCL) and peripheral T-cell (PTCL) lymphomas resulting in DNA …

IRAK-4 inhibition: emavusertib for the treatment of lymphoid and myeloid malignancies

RD Parrondo, M Iqbal, R Von Roemeling… - Frontiers in …, 2023 - frontiersin.org
Several studies have identified mutations in the MYD88L265P gene as a key driver mutation
in several B-cell lymphomas. B-cell lymphomas that harbor the MYD88L265P mutation form …

Clinical advances in epigenetic therapies for lymphoma

AC Rosenthal, JL Munoz, JC Villasboas - Clinical Epigenetics, 2023 - Springer
Background Advances in understanding of cancer biology, genomics, epigenomics, and
immunology have resulted in development of several therapeutic options that expand …