▪ Abstract X-ray crystallography shows the myosin cross-bridge to exist in two conformations,
the beginning and end of the “power stroke.” A long lever-arm undergoes a 60° to 70° …

Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

Background The molecular basis of idiopathic dilated cardiomyopathy, a primary myocardial
disorder that results in reduced contractile function, is largely unknown. Some cases of …

The crystal structures of an expressed vertebrate smooth muscle myosin motor domain (MD)
and a motor domain–essential light chain (ELC) complex (MDE), both with a transition state …

In the past few years genetic, biochemical, and cytolocalization data have implicated
members of the myosin superfamily of actin-based molecular motors in a variety of cellular …

Genetic hearing impairment affects around 1 in every 2,000 births1. The bulk (approximately
70%) of genetic deafness is non-syndromic, in which hearing impairment is not associated …

Chitin is a major component of fungal cell wall and is synthesized by chitin synthases (Chs).
Plant pathogenic fungi normally have multiple chitin synthase genes. To determine their …

The myosin filaments of striated muscle contain a family of enigmatic myosin-binding
proteins (MyBP), MyBP-C and MyBP-H. These modular proteins of the intracellular …

The crystal structure of a proteolytic subfragment from scallop striated muscle myosin,
complexed with MgADP, has been solved at 2.5 Å resolution and reveals an unusual …

The mechanics of the actomyosin interaction have been extensively studied using the
organized filament array of striated muscle. However, the extrapolation of these data to the …