Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

The molecular and physical information coded within the extracellular milieu is informing the
development of a new generation of biomaterials for tissue engineering. Several powerful …

Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of
glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important …

Fluorescence spectroscopy, one of the most informative and sensitive analytical techniques,
has played and continues to play key roles in modern research. Indeed, unraveling the inner …

Epigallocatechin gallates (EGCGs), isolated from green tea, have intrinsic properties such
as anti-oxidant, anti-inflammation, and radical scavenger effects. In this study, we report a …

We describe a simple method for efficiently labeling cell-surface sialic acid–containing
glycans on living animal cells. The method uses mild periodate oxidation to generate an …

This report provides a perspective on metabolic glycoengineering methodology developed
over the past two decades that allows natural sialic acids to be replaced with chemical …

As one of the major types of biomacromolecules in the cell, glycans play essential functional
roles in various biological processes. Compared with proteins and nucleic acids, the …

Breakthroughs in precision cell surface engineering tools are supporting the rapid
development of programmable living assemblies with valuable features for tackling complex …

Layer-by-layer assembly of polyelectrolyte multilayer (PEM) films represents a bottom-up
approach for re-engineering the molecular landscape of cell surfaces with spatially …