Recent patents of pharmaceutical co-crystals: product development on anti-cancer drugs and beyond

AAMS Tharik, SN Meyyanathan - Recent Patents on Anti-Cancer …, 2023 - benthamdirect.com
Background: Scientists, academicians, and researchers from academics and the
pharmaceutical industries have all expressed interest in the design and production of …

Polymorphism in erlotinib hydrochloride: New insights into relative stability, thermal behavior, and structural differences of forms A and B

CT António, AOL Évora, CES Bernardes… - Crystal Growth & …, 2023 - ACS Publications
Erlotinib hydrochloride (EtbHCl), whose polymorphism is still ill-characterized, is an
essential component of the current armamentarium for the treatment of pancreatic and lung …

Stabilizing effect of Soluplus on erlotinib metastable crystal form in microparticles and amorphous solid dispersions

S Jia, S Ning, Y Leng, Q **g, Z Xu, F Ren - Polymers, 2022 - mdpi.com
Microparticles (MPs) and amorphous solid dispersions (SDs) are effective methods to
improve the dissolution of insoluble drugs. However, stability is a concern for these two high …

Polymorph transformation of solid drugs and inhibiting strategies

Y Feng, H Wang, D Wu, K Chen, N Wang, T Wang… - …, 2024 - pubs.rsc.org
Metastable forms and amorphous forms exhibit higher solubility and dissolution rates
compared to stable crystalline forms, making them viable options for pharmaceuticals with …

Preparation of Atorvastatin Calcium-Dipicolinic Acid Multicomponent Solids by Liquid-Assisted Grinding Method to Increase Solubility

Y Wicaksono, SF Tsaniyah, B Wisudyaningsih… - Molekul, 2022 - jos.unsoed.ac.id
Atorvastatin calcium is a cholesterol-lowering drug that is very potent but difficult to dissolve
in water, so its bioavailability is low. In this study, atorvastatin calcium-dipicolinic acid …

Solubility Study of Α Form of Aztreonam in Binary Solvents by Thermodynamic Analysis and Molecular Simulation

Y Dong, W Yang, K Jia, X Liu, Z Li, T Li, Y Li… - Available at SSRN … - papers.ssrn.com
Aztreonam is a β-lactam antibiotic that is effective against aerobic Gram-negative bacteria. In
this work, the solubility of aztreonam (α-form) in five binary mixed solvents (water+ ethanol …