To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

Ubiquitination is a commonly used post-translational modification (PTM) in eukaryotic cells,
which regulates a wide variety of cellular processes, such as differentiation, apoptosis, cell …

Microbial pathogens have coevolved with their hosts, often for millions of years, and in the
process have developed a variety of virulence mechanisms to ensure their survival, typically …

Legionella pneumophila (LP) secretes more than 300 effectors into the host cytosol to
facilitate intracellular replication. One of these effectors, SidH, 253 kDa in size with no …

The pathogenicity of L. pneumophila, the causative agent of Legionnaires' disease, depends
on an arsenal of interacting proteins. Here we describe how surface-associated and …

The bacterial plant pathogen Pseudomonas syringae requires type III secreted effectors
(T3SEs) for pathogenesis. However, a major facet of plant immunity entails the recognition of …

Legionella pneumophila uses over 300 translocated effector proteins to rewire host cells
during infection and create a replicative niche for intracellular growth. To date, several …

Legionella pneumophila grows within membrane-bound vacuoles in phylogenetically
diverse hosts. Intracellular growth requires the function of the Icm/Dot type-IVb secretion …

Legionella pneumophila is an environmentally acquired pathogen that causes respiratory
disease in humans. While the discovery of L. pneumophila is relatively recent compared to …

Work over the past two decades clearly defined a significant role of glycosyltransferase
effectors in the infection strategy of the Gram-negative, respiratory pathogen Legionella …