Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

Calpains are cysteine proteases expressed in skeletal muscle fibers and other cells.
Although calpain was first reported to act as a kinase activating factor in skeletal muscle, the …

Advancements in animal models and cell culture techniques have been invaluable in the
elucidation of the molecular mechanisms that regulate muscle atrophy. However, few …

Objective: Diaphragmatic weakness, due to both atrophy and contractile dysfunction, is a
well-documented response following prolonged mechanical ventilation. Evidence indicates …

Support withdrawal has been currently considered as one of the main factors involved in
regulation of the human locomotor system. For last decades, several authors, including the …

Maintenance of skeletal muscle mass and function is an incredibly nuanced balance of
anabolism and catabolism that can become distorted within different pathological conditions …

Skeletal muscle consists of different fiber types arranged in a mosaic pattern. These fiber
types are characterized by specific functional properties. Slow-type fibers demonstrate a …

Skeletal muscle is capable of changing its structural parameters, metabolic rate and
functional characteristics within a wide range when adapting to various loading regimens …

A mammalian soleus muscle along with other “axial” muscles ensures the stability of the
body under the Earth's gravity. In rat experiments with hindlimb suspension, zero-gravity …

We aimed to explore the effect of the 3-day dry immersion, a model of physical unloading, on
mitochondrial function, transcriptomic and proteomic profiles in a slow-twitch soleus muscle …