Integrated analysis of transcriptomic and proteomic data

S Haider, R Pal - Current genomics, 2013 - ingentaconnect.com
Until recently, understanding the regulatory behavior of cells has been pursued through
independent analysis of the transcriptome or the proteome. Based on the central dogma, it …

Cell biology of diabetic nephropathy: roles of endothelial cells, tubulointerstitial cells and podocytes

Y Maezawa, M Takemoto… - Journal of diabetes …, 2015 - Wiley Online Library
Diabetic nephropathy is the major cause of end‐stage renal failure throughout the world in
both developed and develo** countries. Diabetes affects all cell types of the kidney …

The single-cell transcriptomic landscape of early human diabetic nephropathy

PC Wilson, H Wu, Y Kirita, K Uchimura… - Proceedings of the …, 2019 - National Acad Sciences
Diabetic nephropathy is characterized by damage to both the glomerulus and
tubulointerstitium, but relatively little is known about accompanying cell-specific changes in …

Transcriptome analysis of human diabetic kidney disease

KI Woroniecka, ASD Park, D Mohtat, DB Thomas… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Diabetic kidney disease (DKD) is the single leading cause of kidney failure in
the US, for which a cure has not yet been found. The aim of our study was to provide an …

Carnosine as a Protective Factor in Diabetic Nephropathy: Association With a Leucine Repeat of the Carnosinase Gene CNDP1

B Janssen, D Hohenadel, P Brinkkoetter, V Peters… - Diabetes, 2005 - Am Diabetes Assoc
The risk of diabetic nephropathy is partially genetically determined. Diabetic nephropathy is
linked to a gene locus on chromosome 18q22. 3-q23. We aimed to identify the causative …

Pro-and anti-fibrotic effects of vascular endothelial growth factor in chronic kidney diseases

C Miao, X Zhu, X Wei, M Long, L Jiang, C Li, D **… - Renal failure, 2022 - Taylor & Francis
Renal fibrosis is the inevitable common end-point of all progressive chronic kidney
diseases. The underlying mechanisms of renal fibrosis are complex, and currently there is …

Changing landscape of anti-angiogenic therapy: Novel approaches and clinical perspectives

RN Gacche - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Targeting angiogenesis has remained one of the important aspects in disease biology in
general and cancer in particular. Currently (June 2023), over 593 clinical trials have been …

[HTML][HTML] Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism

G Liang, L Song, Z Chen, Y Qian, J **e, L Zhao, Q Lin… - Kidney international, 2018 - Elsevier
Inflammation plays a central role in the etiology of diabetic nephropathy, a global health
issue. We observed a significant reduction in the renal expression of fibroblast growth factor …

Vascular endothelial growth factor and diabetic complications

B Wirostko, TY Wong, R Simó - Progress in retinal and eye research, 2008 - Elsevier
Intraocular delivery of anti-vascular endothelial growth factor (VEGF) therapies is now used
widely to treat age-related macular degeneration, and is currently undergoing evaluation in …

Molecular mechanisms of diabetic vascular complications

M Kitada, Z Zhang, A Mima… - Journal of diabetes …, 2010 - Wiley Online Library
Diabetic complications are the major causes of morbidity and mortality in patients with
diabetes. Microvascular complications include retinopathy, nephropathy and neuropathy …