Many processes in chemistry and biology involve interactions of a ligand with its molecular
target. Interest in the mechanism governing such interactions has dominated theoretical and …

Nitric oxide (• NO) interactions with biological thiols play crucial, but incompletely
determined, roles in vascular signalling and other biological processes. Here, we highlight …

Cisplatin [cis-diamminedichloroplatinum (II)(cis-DDP)] is one of the most successful
anticancer agents effective against a wide range of solid tumors. However, its use is …

The free radical nitric oxide (NO•) regulates diverse physiological processes from
vasodilation in humans to gas exchange in plants. S-Nitrosoglutathione (GSNO) is …

Strategies to target specific protein cysteines are critical to covalent probe and drug
discovery. 3-Bromo-4, 5-dihydroisoxazole (BDHI) is a natural product-inspired, synthetically …

Abstract Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which
plays a key role in Parkinson's disease (PD). It is one of the most important proteins, which …

Protein S-nitrosation is an important consequence of NO●· metabolism with implications in
physiology and pathology. The mechanisms responsible for S-nitrosation in vivo remain …

Protein S-nitrosation is a post-translational modification that regulates the function of more
than 500 human proteins. Despite its apparent physiological significance, S-nitrosation is …

Glutathione S-transferases (GST) play a prominent role in protecting cells against oxidative
stress. Our previous study showed that the reactive oxygen species (ROS) generated from …

Abstract Glutathione S-transferase A3-3 is the most catalytically efficient steroid isomerase
enzyme known in humans, transforming Δ 5-androstene-3-17-dione into Δ 4-androstene-3 …