Traumatic brain injuries: pathophysiology and potential therapeutic targets
SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …
amongst civilians and military personnel globally. Despite advances in our knowledge of the …
Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications
Stem cell therapy has garnered much attention and application in the past decades for the
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …
Hyaluronan-based hydrogel integrating exosomes for traumatic brain injury repair by promoting angiogenesis and neurogenesis
X Liu, C Wu, Y Zhang, S Chen, J Ding, Z Chen… - Carbohydrate …, 2023 - Elsevier
With wide clinical demands, therapies for traumatic brain injury (TBI) are far from satisfactory.
Combining the merits of stem cells but avoiding the risk of immunologic rejection, bone …
Combining the merits of stem cells but avoiding the risk of immunologic rejection, bone …
Integrated printed BDNF-stimulated HUCMSCs-derived exosomes/collagen/chitosan biological scaffolds with 3D printing technology promoted the remodelling of …
X Liu, J Zhang, X Cheng, P Liu, Q Feng… - Regenerative …, 2023 - academic.oup.com
The restoration of nerve dysfunction after traumatic brain injury (TBI) faces huge challenges
due to the limited self-regenerative abilities of nerve tissues. In situ inductive recovery can …
due to the limited self-regenerative abilities of nerve tissues. In situ inductive recovery can …
[HTML][HTML] Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment
L Wang, D Zhang, Y Ren, S Guo, J Li, S Ma, M Yao… - Materials Today Bio, 2022 - Elsevier
Injectable hydrogel has the advantage to fill the defective area and thereby shows promise
as therapeutic implant or cell/drug delivery vehicle for tissue repair. In this study, an …
as therapeutic implant or cell/drug delivery vehicle for tissue repair. In this study, an …
Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 …
C Zhang, Y Huang, F Ouyang, M Su, W Li… - Journal of …, 2022 - Springer
Background Neuroinflammation in spinal dorsal horn (SDH) plays an important role in the
pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). Mesenchymal stem cell …
pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). Mesenchymal stem cell …
Aging and mesenchymal stem cells: basic concepts, challenges and strategies
M Fraile, N Eiro, LA Costa, A Martín, FJ Vizoso - Biology, 2022 - mdpi.com
Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …
mechanisms, which demand for new therapeutic strategies against their devastating effects …
[HTML][HTML] Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics
Y Zhu, J Ge, C Huang, H Liu, H Jiang - Theranostics, 2021 - ncbi.nlm.nih.gov
Aging frailty is a complex geriatric syndrome that becomes more prevalent with advancing
age. It constitutes a major health problem due to frequent adverse outcomes. Frailty is …
age. It constitutes a major health problem due to frequent adverse outcomes. Frailty is …
Interaction of neural stem cells (NSCs) and mesenchymal stem cells (MSCs) as a promising approach in brain study and nerve regeneration
A Kaminska, K Radoszkiewicz, P Rybkowska… - Cells, 2022 - mdpi.com
Rapid developments in stem cell research in recent years have provided a solid foundation
for their use in medicine. Over the last few years, hundreds of clinical trials have been …
for their use in medicine. Over the last few years, hundreds of clinical trials have been …
Dual-enzymatically cross-linked gelatin hydrogel promotes neural differentiation and neurotrophin secretion of bone marrow-derived mesenchymal stem cells for …
J Li, D Zhang, S Guo, C Zhao, L Wang, S Ma… - International Journal of …, 2021 - Elsevier
Traumatic brain injury (TBI) is one of the most devastating nervous injuries. Neural tissue
engineering based on stem cells and bioactive scaffold is a promising but challenging …
engineering based on stem cells and bioactive scaffold is a promising but challenging …