Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications

A Gowen, F Shah**, S Chand, KE Odegaard… - Frontiers in cell and …, 2020 - frontiersin.org
Stem cell therapy has garnered much attention and application in the past decades for the
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …

Hyaluronan-based hydrogel integrating exosomes for traumatic brain injury repair by promoting angiogenesis and neurogenesis

X Liu, C Wu, Y Zhang, S Chen, J Ding, Z Chen… - Carbohydrate …, 2023 - Elsevier
With wide clinical demands, therapies for traumatic brain injury (TBI) are far from satisfactory.
Combining the merits of stem cells but avoiding the risk of immunologic rejection, bone …

Integrated printed BDNF-stimulated HUCMSCs-derived exosomes/collagen/chitosan biological scaffolds with 3D printing technology promoted the remodelling of …

X Liu, J Zhang, X Cheng, P Liu, Q Feng… - Regenerative …, 2023 - academic.oup.com
The restoration of nerve dysfunction after traumatic brain injury (TBI) faces huge challenges
due to the limited self-regenerative abilities of nerve tissues. In situ inductive recovery can …

[HTML][HTML] Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment

L Wang, D Zhang, Y Ren, S Guo, J Li, S Ma, M Yao… - Materials Today Bio, 2022 - Elsevier
Injectable hydrogel has the advantage to fill the defective area and thereby shows promise
as therapeutic implant or cell/drug delivery vehicle for tissue repair. In this study, an …

Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 …

C Zhang, Y Huang, F Ouyang, M Su, W Li… - Journal of …, 2022 - Springer
Background Neuroinflammation in spinal dorsal horn (SDH) plays an important role in the
pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). Mesenchymal stem cell …

Aging and mesenchymal stem cells: basic concepts, challenges and strategies

M Fraile, N Eiro, LA Costa, A Martín, FJ Vizoso - Biology, 2022 - mdpi.com
Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

[HTML][HTML] Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics

Y Zhu, J Ge, C Huang, H Liu, H Jiang - Theranostics, 2021 - ncbi.nlm.nih.gov
Aging frailty is a complex geriatric syndrome that becomes more prevalent with advancing
age. It constitutes a major health problem due to frequent adverse outcomes. Frailty is …

Interaction of neural stem cells (NSCs) and mesenchymal stem cells (MSCs) as a promising approach in brain study and nerve regeneration

A Kaminska, K Radoszkiewicz, P Rybkowska… - Cells, 2022 - mdpi.com
Rapid developments in stem cell research in recent years have provided a solid foundation
for their use in medicine. Over the last few years, hundreds of clinical trials have been …

Dual-enzymatically cross-linked gelatin hydrogel promotes neural differentiation and neurotrophin secretion of bone marrow-derived mesenchymal stem cells for …

J Li, D Zhang, S Guo, C Zhao, L Wang, S Ma… - International Journal of …, 2021 - Elsevier
Traumatic brain injury (TBI) is one of the most devastating nervous injuries. Neural tissue
engineering based on stem cells and bioactive scaffold is a promising but challenging …