RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

In Trypanosoma brucei, the editosome, composed of RNA-editing substrate-binding
complex (RESC) and RNA-editing catalytic complex (RECC), orchestrates guide RNA …

Most mitochondrial mRNAs in kinetoplastids require editing, that is, the posttranscriptional
insertion and deletion of uridine nucleotides that are specified by guide RNAs and catalyzed …

▪ Abstract Over the past several decades, our knowledge of the origin and evolution of
mitochondria has been greatly advanced by determination of complete mitochondrial …

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

Tandem affinity purification (TAP) allows for rapid and efficient purification of epitope-tagged
protein complexes from crude extracts under native conditions. The method was established …

Kinetoplastids are flagellated protozoans, whose members include the pathogens
Trypanosoma brucei, T. cruzi and Leishmania species, that are considered among the …

RNA uridylation is a potent and widespread posttranscriptional regulator of gene
expression. RNA uridylation has been detected in a range of eukaryotes including …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …