Bone morphogenetic protein-2 (BMP-2) is currently the only Food and Drug Administration
(FDA)-approved osteoinductive growth factor used as a bone graft substitute. However, with …

Human osteogenic differentiation is a complex and well-orchestrated process which
involves a plethora of molecular players and cellular processes. A growing number of …

Over the last decade, stem cell-based regenerative medicine has progressed to clinical
testing and therapeutic applications. The applications range from infusions of autologous …

Adipose-derived stromal/stem cells (ASCs) seems to be a promising regenerative
therapeutic agent due to the minimally invasive approach of their harvest and multi-lineage …

Musculoskeletal disorders are the leading causes of physical disabilities worldwide. The
poor self-repair capacity of musculoskeletal tissues and the absence of effective therapies …

The lack of a functional vascular supply has been identified as a major challenge limiting the
clinical introduction of stem cell-based bone tissue engineering (BTE) for the repair of large …

Periodontal tissue engineering involves a multi-disciplinary approach towards the
regeneration of periodontal ligament, cementum and alveolar bone surrounding teeth …

Despite the high regenerative capacity of bone tissue, there are some cases where bone
repair is insufficient for a complete functional and structural recovery after damage. Current …

Bio-inspired adhesive hydrogels have been applied to cell and drug delivery systems to
address various tissue defects and disorders. However, adhesive hydrogels functionalized …

Mesenchymal stem cells (MSCs) are a major component of various forms of tissue
engineering. MSCs have self‐renewal and multidifferential potential. Osteogenic …