BACKGROUND The defining feature of eukaryotic cells is the presence of membrane-bound
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …

Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most
frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …

The endoplasmic reticulum (ER) and mitochondria accumulate Ca2+ within their lumens to
regulate numerous cell functions. However, determining the dynamics of intraorganellar …

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …

Abbreviations used in this paper: CERT, ceramide transport protein; DHPR, dihydropyridine
receptor; E-Syt, extended synaptotagmin; FFAT, phenylalanines in an acid tract; LTP, lipid …

Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …

Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell,
allowing the segregation of sometimes incompatible biochemical reactions into specific …