Emerging advances in defining the molecular and therapeutic landscape of small-cell lung cancer
Small-cell lung cancer (SCLC) has traditionally been considered a recalcitrant cancer with a
dismal prognosis, with only modest advances in therapeutic strategies over the past several …
dismal prognosis, with only modest advances in therapeutic strategies over the past several …
Neuroendocrine neoplasms of the lung and gastrointestinal system: convergent biology and a path to better therapies
K Kawasaki, N Rekhtman… - Nature Reviews …, 2023 - nature.com
Neuroendocrine neoplasms (NENs) can develop in almost any organ and span a spectrum
from well-differentiated and indolent neuroendocrine tumours (NETs) to poorly differentiated …
from well-differentiated and indolent neuroendocrine tumours (NETs) to poorly differentiated …
Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histologic transformation
Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …
Chromothripsis-mediated small cell lung carcinoma
N Rekhtman, SE Tischfield, CA Febres-Aldana… - Cancer …, 2025 - aacrjournals.org
Small cell lung carcinoma (SCLC) is a highly aggressive malignancy that is typically
associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here, we …
associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here, we …
Small cell lung carcinoma: current diagnosis, biomarkers, and treatment options with future perspectives
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid
proliferation, early dissemination, acquired therapy resistance, and poor prognosis. Early …
proliferation, early dissemination, acquired therapy resistance, and poor prognosis. Early …
[HTML][HTML] Small cell lung cancer profiling: an updated synthesis of subtypes, vulnerabilities, and plasticity
Small cell lung cancer (SCLC) is a devastating disease with high proliferative and metastatic
capacity. SCLC has been classified into molecular subtypes based on differential …
capacity. SCLC has been classified into molecular subtypes based on differential …
Systemic therapy for small-cell lung cancer: ASCO-Ontario health (cancer care Ontario) guideline
H Khurshid, N Ismaila, J Bian, R Dabney… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE To provide evidence-based recommendations to practicing clinicians on the
management of patients with small-cell lung cancer. METHODS An Expert Panel of medical …
management of patients with small-cell lung cancer. METHODS An Expert Panel of medical …
SAR-096: Phase II clinical trial of ribociclib in combination with everolimus in advanced dedifferentiated liposarcoma (DDL) and leiomyosarcoma (LMS)
S Movva, S Matloob, EA Handorf, E Choy… - Clinical Cancer …, 2024 - AACR
Purpose: Dedifferentiated liposarcoma (DDL) and leiomyosarcoma (LMS) are two common
subtypes of soft-tissue sarcoma, a rare group of diseases for which new treatments are …
subtypes of soft-tissue sarcoma, a rare group of diseases for which new treatments are …
PD‐L1 and nectin‐4 expression and genomic characterization of bladder cancer with divergent differentiation
DJ Martini, KB Case, D Gratz, K Pellegrini, E Beagle… - Cancer, 2024 - Wiley Online Library
Background Bladder cancer with divergent differentiation (BCDD) comprises a
heterogenous group of tumors with a poor prognosis, and differential expression of nectin‐4 …
heterogenous group of tumors with a poor prognosis, and differential expression of nectin‐4 …
Genetically-engineered mouse models of small cell lung cancer: the next generation
Small cell lung cancer (SCLC) remains the most fatal form of lung cancer, with patients in
dire need of new and effective therapeutic approaches. Modeling SCLC in an …
dire need of new and effective therapeutic approaches. Modeling SCLC in an …