Over the last decade, we have seen an enormous increase in the number of experimental
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …

TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to
the family of two-pore domain potassium channels. This gene subfamily is constitutively …

The two-pore domain potassium (K2P) channels TASK-1 (KCNK3) and TASK-3 (KCNK9)
are important determinants of background K+ conductance and membrane potential. TASK …

Although well documented drug therapies are available for the management of ventricular
hypertrophy (VH) and heart failure (HF), most patients nonetheless experience a downhill …

Pulmonary arterial (PA) hypertension (PAH) is a severe cardiopulmonary disease that may
be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions …

Background and Purpose Signalling through phospholipase C (PLC) controls many cellular
processes. Much information on the relevance of this important pathway has been derived …

Key points The TASK‐1 channel gene (KCNK3) has been identified as a possible disease‐
causing gene in heritable pulmonary arterial hypertension (PAH). In the present study, we …

Analyzing a patient with progressive and severe cardiac conduction disorder combined with
idiopathic ventricular fibrillation (IVF), we identified a splice site mutation in the sodium …

Among human birth defect syndromes, malformations affecting the face are perhaps the
most striking due to cultural and psychological expectations of facial shape. One such …

TASK-1 channels have emerged as promising drug targets against atrial fibrillation, the most
common arrhythmia in the elderly. While TASK-3, the closest relative of TASK-1, was …