Outer membrane biogenesis
A Konovalova, DE Kahne… - Annual review of …, 2017 - annualreviews.org
The hallmark of gram-negative bacteria and organelles such as mitochondria and
chloroplasts is the presence of an outer membrane. In bacteria such as Escherichia coli, the …
chloroplasts is the presence of an outer membrane. In bacteria such as Escherichia coli, the …
Outer membrane protein biogenesis in Gram-negative bacteria
SE Rollauer, MA Sooreshjani… - … Transactions of the …, 2015 - royalsocietypublishing.org
Gram-negative bacteria contain a double membrane which serves for both protection and for
providing nutrients for viability. The outermost of these membranes is called the outer …
providing nutrients for viability. The outermost of these membranes is called the outer …
Structural insight into the biogenesis of β-barrel membrane proteins
Abstract β-barrel membrane proteins are essential for nutrient import, signalling, motility and
survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is …
survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is …
Structural basis of outer membrane protein insertion by the BAM complex
All Gram-negative bacteria, mitochondria and chloroplasts have outer membrane proteins
(OMPs) that perform many fundamental biological processes. The OMPs in Gram-negative …
(OMPs) that perform many fundamental biological processes. The OMPs in Gram-negative …
Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry
DS Chorev, LA Baker, D Wu, V Beilsten-Edmands… - Science, 2018 - science.org
Membrane proteins reside in lipid bilayers and are typically extracted from this environment
for study, which often compromises their integrity. In this work, we ejected intact assemblies …
for study, which often compromises their integrity. In this work, we ejected intact assemblies …
The structure of the β-barrel assembly machinery complex
J Bakelar, SK Buchanan, N Noinaj - Science, 2016 - science.org
β-Barrel outer membrane proteins (OMPs) are found in the outer membranes of Gram-
negative bacteria and are essential for nutrient import, signaling, and adhesion. A 200 …
negative bacteria and are essential for nutrient import, signaling, and adhesion. A 200 …
The β-barrel assembly machinery in motion
In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins (OMPs) is
mediated by the β-barrel assembly machinery (BAM) complex. During the past decade …
mediated by the β-barrel assembly machinery (BAM) complex. During the past decade …
Monoclonal antibody targeting the β-barrel assembly machine of Escherichia coli is bactericidal
The folding and insertion of integral β-barrel membrane proteins into the outer membrane of
Gram-negative bacteria is required for viability and bacterial pathogenesis. Unfortunately …
Gram-negative bacteria is required for viability and bacterial pathogenesis. Unfortunately …
Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM
The β-barrel assembly machinery (BAM) is a∼ 203 kDa complex of five proteins (BamA–E),
which is essential for viability in E. coli. BAM promotes the folding and insertion of β-barrel …
which is essential for viability in E. coli. BAM promotes the folding and insertion of β-barrel …
Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins
In Gram-negative bacteria, the assembly of β-barrel outer-membrane proteins (OMPs)
requires the β-barrel–assembly machinery (BAM) complex. We determined the crystal …
requires the β-barrel–assembly machinery (BAM) complex. We determined the crystal …