Activity-based fluorescence diagnostics for cancer

K Fujita, Y Urano - Chemical reviews, 2024 - ACS Publications
Fluorescence imaging is one of the most promising approaches to achieve intraoperative
assessment of the tumor/normal tissue margins during cancer surgery. This is critical to …

Peptide-based agents for cancer treatment: current applications and future directions

NTT Nhàn, T Yamada, KH Yamada - International Journal of Molecular …, 2023 - mdpi.com
Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial

JG de Wit, J Vonk, FJ Voskuil, SAHJ de Visscher… - Nature …, 2023 - nature.com
Inadequate surgical margins occur frequently in oral squamous cell carcinoma surgery.
Fluorescence molecular imaging (FMI) has been explored for intraoperative margin …

Intraoperative imaging in pathology-assisted surgery

FJ Voskuil, J Vonk, B van der Vegt, S Kruijff… - Nature biomedical …, 2022 - nature.com
The pathological assessment of surgical specimens during surgery can reduce the
incidence of positive resection margins, which otherwise can result in additional surgeries or …

Advances in drug delivery for post-surgical cancer treatment

LL Bu, J Yan, Z Wang, H Ruan, Q Chen, V Gunadhi… - Biomaterials, 2019 - Elsevier
Surgery remains a primary modality of treatment for the majority of solid tumor malignancies.
While advancements in surgical technique and instrumentation have improved the quality of …

Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma

U Uslu, T Da, CA Assenmacher, J Scholler… - Science …, 2023 - science.org
Incomplete surgery of solid tumors is a risk factor for primary treatment failure. Here, we have
investigated whether chimeric antigen receptor T cells (CARTs) could be used as an …

Image-guided cancer surgery: a narrative review on imaging modalities and emerging nanotechnology strategies

B Bortot, A Mangogna, G Di Lorenzo, G Stabile… - Journal of …, 2023 - Springer
Surgical resection is the cornerstone of solid tumour treatment. Current techniques for
evaluating margin statuses, such as frozen section, imprint cytology, and intraoperative …

Foundation models for fast, label-free detection of glioma infiltration

A Kondepudi, M Pekmezci, X Hou, K Scotford, C Jiang… - Nature, 2024 - nature.com
A critical challenge in glioma treatment is detecting tumour infiltration during surgery to
achieve safe maximal resection,–. Unfortunately, safely resectable residual tumour is found …

Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: a quantitative dose-escalation study

FJ Voskuil, SJ de Jongh, WTR Hooghiemstra… - …, 2020 - pmc.ncbi.nlm.nih.gov
Tumor-positive resection margins are present in up to 23% of head and neck cancer (HNC)
surgeries, as intraoperative techniques for real-time evaluation of the resection margins are …

AND-gate contrast agents for enhanced fluorescence-guided surgery

JC Widen, M Tholen, JJ Yim, A Antaris… - Nature biomedical …, 2021 - nature.com
Surgical resection of tumours requires precisely locating and defining the margins between
lesions and normal tissue. However, this is made difficult by irregular margin borders …