Oxidative stress, mitochondrial dysfunction, and aging
H Cui, Y Kong, H Zhang - Journal of signal transduction, 2012 - Wiley Online Library
Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …
functions and increase in mortality that is often accompanied by many pathological …
Maintenance and expression of mammalian mitochondrial DNA
CM Gustafsson, M Falkenberg… - Annual review of …, 2016 - annualreviews.org
Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …
function of the oxidative phosphorylation system, which is composed of four respiratory …
[BOOK][B] Bioenergetics
DG Nicholls - 2013 - books.google.com
Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …
many newly determined protein structures that provide molecular insight into chemiosmotic …
[HTML][HTML] Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA
We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth,
and that tumor formation is associated with acquisition of mtDNA from host cells. This leads …
and that tumor formation is associated with acquisition of mtDNA from host cells. This leads …
Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers
Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-develo**
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …
Base-resolution map** reveals distinct m1A methylome in nuclear-and mitochondrial-encoded transcripts
Gene expression can be post-transcriptionally regulated via dynamic and reversible RNA
modifications. N 1-methyladenosine (m 1 A) is a recently identified mRNA modification; …
modifications. N 1-methyladenosine (m 1 A) is a recently identified mRNA modification; …
Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
Mitochondria are essential organelles within the cell where most ATP is produced through
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …
[HTML][HTML] Mitochondrial DNA mutations and human disease
HAL Tuppen, EL Blakely, DM Turnbull… - Biochimica et Biophysica …, 2010 - Elsevier
Mitochondrial disorders are a group of clinically heterogeneous diseases, commonly
defined by a lack of cellular energy due to oxidative phosphorylation (OXPHOS) defects …
defined by a lack of cellular energy due to oxidative phosphorylation (OXPHOS) defects …
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA
C Kukat, CA Wurm, H Spåhr… - Proceedings of the …, 2011 - National Acad Sciences
Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial
nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial …
nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial …
Role and mechanisms of mitophagy in liver diseases
The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …