Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

Nucleation from solution is fundamental to many natural and industrial processes. The
understanding of molecular mechanism of nucleation from solution is conducive to predict …

A pair of popular thermodynamic models for pharmaceutical applications, namely, the
perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state and the …

Synthon preference is perceived in the pyridyl salts of multi-functional organo-sulfonates
and validated through density functional theory (DFT) studies. The salt 1 of 5-sulfosalicylic …

Liquid–liquid phase separation (LLPS) has been proven to play a key role in molecular self-
assembly both in vivo and in vitro, and it is of great significance for life science and materials …

The crystal structure and thermodynamic properties of Tinidazole (TNZ), an antiprotozoal
and antibacterial drug, were investigated in the solid phase and liquid phase. The solubility …

Cinnamalmalononitrile (CM) derivatives have been shown to exhibit a strong
photomechanical response in the crystal form. In this paper, the effects of fluorine …

In this paper, the nucleation behavior of glutaric acid (GA) in solvents with different hydrogen-
bond donating (HBD) capabilities was studied using a metastable zone width (MSZW) …

The equilibrium solubility of isophthalic acid (IPA) in three aqueous solutions of
betaine/propylene glycol (Bet/PG, 1: 5 M ratio), betaine/ethylene glycol (Bet/EG, 1: 3 M ratio) …

Cosolvency has been observed in many systems. To reveal the mechanism of cosolvency
from the molecular level, the effects of molecular conformation, supramolecular clusters, and …