Genetics and biology of prostate cancer
Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …
many common phenotypes of biomedical importance. These advances have been the result …
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
FR Schumacher, AA Al Olama, SI Berndt, S Benlloch… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) and fine-map** efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …
[HTML][HTML] A proteome-scale map of the human interactome network
Just as reference genome sequences revolutionized human genetics, reference maps of
interactome networks will be critical to fully understand genotype-phenotype relationships …
interactome networks will be critical to fully understand genotype-phenotype relationships …
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
LA Hindorff, P Sethupathy, HA Junkins… - Proceedings of the …, 2009 - National Acad Sciences
We have developed an online catalog of SNP-trait associations from published genome-
wide association studies for use in investigating genomic characteristics of trait/disease …
wide association studies for use in investigating genomic characteristics of trait/disease …
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …
(T2D) and 38,987 controls of European descent and following up previously unidentified …
Genomewide association studies and assessment of the risk of disease
TA Manolio - New England journal of medicine, 2010 - Mass Medical Soc
Over the past 5 years, genomewide association studies have yielded a wealth of insight into
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …
Pleiotropy in complex traits: challenges and strategies
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
Genetic map** in human disease
Genetic map** provides a powerful approach to identify genes and biological processes
underlying any trait influenced by inheritance, including human diseases. We discuss the …
underlying any trait influenced by inheritance, including human diseases. We discuss the …