The retinoblastoma protein RB and the transcription factor p53 are central tumor
suppressors. They are often found inactivated in various tumor types. Both proteins play …

Human papillomaviruses (HPVs) have evolved over millions of years to propagate
themselves in a range of different animal species including humans. Viruses that have co …

Human papillomaviruses (HPVs) comprise a diverse group, and have different epithelial
tropisms and life-cycle strategies. Many HPVs are classified as low-risk, as they are only …

Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A
unique aspect of human papillomavirus molecular biology involves dependence on the …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

DNA replication in cancer cells is accompanied by stalling and collapse of the replication
fork and signalling in response to DNA damage and/or premature mitosis; these processes …

Background Medulloblastoma is the most common malignant brain tumor in children.
Despite recent improvements in cure rates, prediction of disease outcome remains a major …

In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and
reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic …

Viruses, as obligate intracellular parasites, are the pathogens that have the most intimate
relationship with their host, and as such, their genomes have been shaped directly by …

Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was
demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in∼ 80% of …