Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer,
with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently …

DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …

Lactate was implicated in the activation of hepatic stellate cells (HSCs). However, the
mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag …

Brain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and
ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet …

Bladder cancer is lethal in its advanced, muscle-invasive phase with very limited therapeutic
advances,. Recent molecular characterization has defined new (epi) genetic drivers and …

Standard induction chemotherapy, consisting of an anthracycline and cytarabine, has been
the first-line therapy for many years to treat acute myeloid leukemia (AML). Although this …

Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally
well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic …

Granulocytic myeloid-derived suppressor cells (G-MDSCs) promote tumor growth and
immunosuppression in multiple myeloma (MM). However, their phenotype is not well …

Cancer development involves both genetic and epigenetic alterations. Aberrant epigenetic
modifications are reversible, allowing excellent opportunities for therapeutic intervention …

Polypharmacology plays an important role in defining response and adverse effects of
drugs. For some mechanisms, experimentally map** polypharmacology is commonplace …