Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Background: Depression and anxiety are two mental disorders that are often comorbid.
However, the associations of long-term air pollution exposure with depression and anxiety …

This narrative review discusses how peripheral and central inflammation processes affect
brain function and structure in depression, and reports on recent peripheral inflammatory …

As the kynurenine pathway's links to inflammation, the immune system, and neurological
disorders became more apparent, it attracted more and more attention. It is the main …

Clinical depression is a multifactorial disorder and one of the leading causes of disability
worldwide. The alterations in tryptophan metabolism such as changes in the levels of …

The central nervous system (CNS) is the final frontier in drug delivery because of the blood–
brain barrier (BBB), which poses significant barriers to the access of most drugs to their …

Millions of individuals around the world are afflicted with Parkinson's disease (PD), a
prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished …

Background Defining the presence of acute and chronic brain inflammation remains a
challenge to clinicians due to the heterogeneity of clinical presentations and aetiologies …