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[HTML][HTML] Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process
A Salminen - Ageing Research Reviews, 2023 - Elsevier
Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …
Brain–body communication in metabolic control
A thorough understanding of the mechanisms controlling energy homeostasis is needed to
prevent and treat metabolic morbidities. While the contribution of organs such as the liver …
prevent and treat metabolic morbidities. While the contribution of organs such as the liver …
Brain-muscle communication prevents muscle aging by maintaining daily physiology
A molecular clock network is crucial for daily physiology and maintaining organismal health.
We examined the interactions and importance of intratissue clock networks in muscle tissue …
We examined the interactions and importance of intratissue clock networks in muscle tissue …
[HTML][HTML] Liver and muscle circadian clocks cooperate to support glucose tolerance in mice
Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the
rhythms generated by the concerted activity of these clocks is associated with metabolic …
rhythms generated by the concerted activity of these clocks is associated with metabolic …
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis.
To dissect daily inter-tissue communication, we constructed a mouse minimal clock network …
To dissect daily inter-tissue communication, we constructed a mouse minimal clock network …
Circadian immunity from bench to bedside: a practical guide
H Mok, E Ostendorf, A Ganninger, AJ Adler… - The Journal of clinical …, 2024 - jci.org
The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …
cycles of activity to function properly. Daily rhythms in immune function are an expanding …
Meta-analysis of diurnal transcriptomics in mouse liver reveals low repeatability of rhythm analyses
To assess the consistency of biological rhythms across studies, 57 public mouse liver tissue
timeseries totaling 1096 RNA-seq samples were obtained and analyzed. Only the control …
timeseries totaling 1096 RNA-seq samples were obtained and analyzed. Only the control …
[HTML][HTML] Targeted Bmal1 restoration in muscle prolongs lifespan with systemic health effects in aging model
Disruption of the circadian clock in skeletal muscle worsens local and systemic health,
leading to decreased muscle strength, metabolic dysfunction, and aging-like phenotypes …
leading to decreased muscle strength, metabolic dysfunction, and aging-like phenotypes …
Circadian de (regulation) in physiology: implications for disease and treatment
Time plays a crucial role in the regulation of physiological processes. Without a temporal
control system, animals would be unprepared for cyclic environmental changes, negatively …
control system, animals would be unprepared for cyclic environmental changes, negatively …
[HTML][HTML] Impact of Bmal1 rescue and time-restricted feeding on liver and muscle proteomes during the active phase in mice
Molecular clocks and daily feeding cycles support metabolism in peripheral tissues.
Although the roles of local clocks and feeding are well defined at the transcriptional level …
Although the roles of local clocks and feeding are well defined at the transcriptional level …