IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity
M Gómez-Herranz, J Taylor, RD Sloan - Journal of Biological Chemistry, 2023 - ASBMB
Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
[BOOK][B] RNA, the epicenter of genetic information
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
Spotlight on TAP and its vital role in antigen presentation and cross-presentation
I Mantel, BA Sadiq, JM Blander - Molecular immunology, 2022 - Elsevier
In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible
for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded …
for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded …
Human leukocyte antigen super-locus: nexus of genomic supergenes, SNPs, indels, transcripts, and haplotypes
Abstract The human Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen
(HLA) super-locus is a highly polymorphic genomic region that encodes more than 140 …
(HLA) super-locus is a highly polymorphic genomic region that encodes more than 140 …
B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy
Y Zhao, Y Cao, Y Chen, L Wu, H Hang, C Jiang… - …, 2021 - Wiley Online Library
Loss of the B2M gene is associated with tumour immune escape and resistance to
immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an …
immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an …
Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance
A Balasubramanian, T John… - Biochemical Society …, 2022 - portlandpress.com
Evading immune destruction is one of the hallmarks of cancer. A key mechanism of immune
evasion deployed by tumour cells is to reduce neoantigen presentation through down …
evasion deployed by tumour cells is to reduce neoantigen presentation through down …
Long non-coding RNAs: emerging regulators for chemo/immunotherapy resistance in cancer stem cells
C Shen, C Yang, B **
anti-tumor immunity by tumor cells. This study was conducted to compare HLA class I …
anti-tumor immunity by tumor cells. This study was conducted to compare HLA class I …
HLA-A+ tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous …
D Zhang, D Jiang, L Jiang, J Ma, X Wang, X Xu… - British Journal of …, 2024 - nature.com
Background Immune checkpoint blockade (ICB) therapy provides remarkable clinical
benefits for multiple cancer types. However, the overall response rate to ICB therapy …
benefits for multiple cancer types. However, the overall response rate to ICB therapy …
SNP-density crossover maps of polymorphic transposable elements and HLA genes within MHC class I haplotype blocks and junction
The genomic region (~ 4 Mb) of the human major histocompatibility complex (MHC) on
chromosome 6p21 is a prime model for the study and understanding of conserved …
chromosome 6p21 is a prime model for the study and understanding of conserved …