One-pot chemo-and photo-enzymatic linear cascade processes

JM Carceller, KS Arias, MJ Climent, S Iborra… - Chemical Society …, 2024 - pubs.rsc.org
The combination of chemo-and photocatalyses with biocatalysis, which couples the flexible
reactivity of the photo-and chemocatalysts with the highly selective and environmentally …

Resource utilization of carbon dioxide and nitrate to produce value-added organonitrogen compounds through an electrochemical approach

K Yu, H Wang, W Yu, S Li, X Zhang, Z Bian - Applied Catalysis B …, 2024 - Elsevier
Excess CO 2 and NO 3-released by human industrial activities have contributed to the
deterioration of the global environment. Simultaneous activation and reduction of CO 2 and …

Combinatorial gene inactivation of aldehyde dehydrogenases mitigates aldehyde oxidation catalyzed by E. coli resting cells

ND Butler, SR Anderson, RM Dickey, P Nain… - Metabolic …, 2023 - Elsevier
Aldehydes are attractive chemical targets both as end products in the flavors and fragrances
industry and as synthetic intermediates due to their propensity for C–C bond formation …

Selective biocatalytic defunctionalization of raw materials

R Wohlgemuth - ChemSusChem, 2022 - Wiley Online Library
Biobased raw materials, such as carbohydrates, amino acids, nucleotides, or lipids contain
valuable functional groups with oxygen and nitrogen atoms. An abundance of many …

Engineered aldoxime dehydratase to enable the chemoenzymatic conversion of benzyl amines to aromatic nitriles

Q **ao, Y Feng, L Chen, M Li, P Zhang, Q Wang… - Bioorganic …, 2023 - Elsevier
A chemoenzymatic strategy has been implemented to synthesize nitriles from benzyl amines
under mild conditions. Aldoxime dehydratase (Oxd) plays a decisive role to convert …

Biocatalytic carboxylate reduction–recent advances and new enzymes

M Winkler, JG Ling - ChemCatChem, 2022 - Wiley Online Library
Carboxylate reductases (CARs) are valuable catalysts for the selective one‐step reduction
of carboxylic acids to their corresponding aldehydes. In recent years, numerous new CARs …

Organic acid to nitrile: a chemoenzymatic three‐step route

M Winkler, M Horvat, A Schiefer… - Advanced Synthesis …, 2023 - Wiley Online Library
Various widely applied compounds contain cyano‐groups, and this functional group serves
as a chemical handle for a whole range of different reactions. We report a cyanide free …

Scanning aldoxime dehydratase sequence space and characterization of a new aldoxime dehydratase from Fusarium vanettenii

B Křístková, R Rädisch, N Kulik, M Horvat… - Enzyme and Microbial …, 2023 - Elsevier
The aim of this work was to map the sequence space of aldoxime dehydratases (Oxds) as
enzymes with great potential for nitrile synthesis. Microbes contain an abundance of putative …

Programing a cyanide-free transformation of aldehydes to nitriles and one-pot synthesis of amides through tandem chemo-enzymatic cascades

H Zheng, Q **ao, F Mao, A Wang, M Li, Q Wang… - RSC …, 2022 - pubs.rsc.org
Nitriles are broadly applied to synthesize pharmaceuticals, agrochemicals, and materials
because of their versatile transformation. Although various methods have been developed …

Enzymatic properties of a non-classical aldoxime dehydratase capable of producing alkyl and arylalkyl nitriles

X Pei, Q **ao, Y Feng, L Chen, F Yang, Q Wang… - Applied Microbiology …, 2023 - Springer
Nitriles are of significant interest in the flavor and fragrance industries with potential
application in cosmetics due to their higher stability than analogous aldehydes. However …