Small-angle scattering (SAS) is a technique that is able to probe the structural organization
of matter and quantify its response to changes in external conditions. X-ray and neutron …

Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

In a wide variety of cellular settings, from organelle transport to muscle contraction, Ca2+
binding to members of the EF hand family of proteins controls the interaction between actin …

The interaction of troponin-C (TnC) with troponin-I (TnI) plays a central role in skeletal and
cardiac muscle contraction. We have recently shown that the binding of Ca2+ to cardiac TnC …

Fourteen monoclonal antibodies (mAbs) against human cardiac troponin I (cTnI) were
generated by commonly used experimental techniques. All these antibodies, as well as …

We have analyzed by different immunological methods the proteolytic degradation of
cardiac troponin I (cTnI) in human necrotic tissue and in serum. cTnI is susceptible to …

This review discusses the structure and properties of the isolated components of troponin,
their interaction, and the mechanisms of regulation of contractile activity of skeletal and …

Introduction 3. Subunit structure-function, subunit-subunit interactions, isoforms, and tissue
distribution 3.1. Subunit structure-function, subunit-subunit interactions 3.1. 1. The gamma …

TN-I occurs as a homologous group of proteins which form part of the regulatory system of
vertebrate and invertebrate striated muscle. These proteins are present in vertebrate muscle …

Hypertrophic cardiomyopathy (HCM) is one of the most frequently occurring inherited
cardiac disorders, affecting up to 1 in 500 of the population. Molecular genetic analysis has …