Current understanding of the molecular and cellular pathology of diabetic retinopathy

DA Antonetti, PS Silva, AW Stitt - Nature Reviews Endocrinology, 2021 - nature.com
Diabetes mellitus has profound effects on multiple organ systems; however, the loss of
vision caused by diabetic retinopathy might be one of the most impactful in a patient's life …

Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives

MF Dias, K Joo, JA Kemp, SL Fialho… - Progress in retinal and …, 2018 - Elsevier
Retinitis Pigmentosa (RP) is a hereditary retinopathy that affects about 2.5 million people
worldwide. It is characterized with progressive loss of rods and cones and causes severe …

Vision loss after intravitreal injection of autologous “stem cells” for AMD

AE Kuriyan, TA Albini, JH Townsend… - … England Journal of …, 2017 - Mass Medical Soc
Adipose tissue–derived “stem cells” have been increasingly used by “stem-cell clinics” in the
United States and elsewhere to treat a variety of disorders. We evaluated three patients in …

[HTML][HTML] Retinal stem cell transplantation: Balancing safety and potential

MS Singh, SS Park, TA Albini, MV Canto-Soler… - Progress in retinal and …, 2020 - Elsevier
Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

[HTML][HTML] Stemming retinal regeneration with pluripotent stem cells

ZB **, ML Gao, WL Deng, KC Wu, S Sugita… - Progress in retinal and …, 2019 - Elsevier
Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

Regenerating eye tissues to preserve and restore vision

JH Stern, Y Tian, J Funderburgh, G Pellegrini, K Zhang… - Cell stem cell, 2018 - cell.com
Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding
disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age …

Retinitis pigmentosa: progress in molecular pathology and biotherapeutical strategies

W Liu, S Liu, P Li, K Yao - International Journal of Molecular Sciences, 2022 - mdpi.com
Retinitis pigmentosa (RP) is genetically heterogeneous retinopathy caused by
photoreceptor cell death and retinal pigment epithelial atrophy that eventually results in …

Bioengineering strategies for restoring vision

J Cehajic-Kapetanovic, MS Singh, E Zrenner… - Nature biomedical …, 2023 - nature.com
Late-stage retinal degenerative disease involving photoreceptor loss can be treated by
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …

[HTML][HTML] Stem cell treatment of degenerative eye disease

B Mead, M Berry, A Logan, RAH Scott, W Leadbeater… - Stem cell …, 2015 - Elsevier
Stem cell therapies are being explored extensively as treatments for degenerative eye
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …

Review of adaptive optics OCT (AO-OCT): principles and applications for retinal imaging

M Pircher, RJ Zawadzki - Biomedical optics express, 2017 - opg.optica.org
In vivo imaging of the human retina with a resolution that allows visualization of cellular
structures has proven to be essential to broaden our knowledge about the physiology of this …